Gut microbial metabolites in obesity, NAFLD and T2DM. Liver gutt represent a major health burden worldwide. The dextran sulfate sodium DSS -induced colitis murine model is widely used.

Polyphenols and gut health -

The two apples also upregulated the expression of 18 genes, 16 of which were related to immunity. This study serves as a good reminder to include many kinds of foods in the diet since varieties of the same fruit can contain different phytochemicals.

Anthocyanins have been studied for their effects on metabolic health by way of the microbiome. Mice treated with anthocyanins and proanthocyanidins exhibited improved insulin sensitivity. The mice were fed a high fat, high sucrose HFHS diet, and those that also received proanthocyanidin supplementation experienced less weight gain and adipose tissue accumulation compared to those only on the HFHS diet.

Germ-free mice that received a fecal microbiota transplant from the HFHS mice experienced consistent metabolic changes with the first group, suggesting that the microbiota was responsible for the polyphenolic effects. Dietary analyses of adults in northern Germany demonstrated that higher intakes of anthocyanins were associated with lower levels of visceral adipose tissue , which is the fat that accumulates around organs.

A higher intake of anthocyanins also correlated with greater microbial diversity and abundance. There were significant associations between lower visceral adipose tissue and specific bacterial genera such as Roseburia.

Finally, a small group of overweight and obese adults were given a mixture of inulin, beta-glucan, and anthocyanins the equivalent of two cups of blueberries. After four weeks, participants experienced improved glucose tolerance and satiety. Short-chain fatty acids, which increased in this study, stimulate satiety hormones such as peptide YY.

Resveratrol is a stilbene compound that is found in grapes, wine, peanuts, cocoa, and berries. Some of the health benefits of the Mediterranean diet may be attributed to the resveratrol found in red wine.

Trimethylamine N-oxide TMAO is a metabolite produced by gut bacteria that is thought to contribute to cardiovascular disease. After four weeks of resveratrol-rich grape extract supplementation, serum levels of TMAO were significantly lower in the treatment group as compared to placebo Intra-amniotic injections of resveratrol and pterostilbene in Cornish broiler hatchlings led to alterations in gut function , mineral levels, and inflammatory cytokines.

The length and diameter of the intestinal microvilli were significantly increased. The microvilli are hairlike projections that play a direct role in nutrient absorption. Liver and serum iron and zinc levels, as well as calcium and magnesium metabolism markers, were greater in the treatment group, perhaps due to the strength of the microvilli.

There was also a significant increase in the diameter of goblet cells, which are responsible for producing the mucus that protects the intestinal wall.

Firmicutes levels were decreased, which is noteworthy since this bacterial phylum is typically associated with obesity. A murine model of diabetic nephropathy demonstrated the ability of resveratrol to impact intestinal permeability and inflammation by decreasing proinflammatory cytokines such as IFN-γ and TNF-α.

The abundance of Bacteroides , Odoribacter , Parabacteroides , and other genera were also positively influenced. Anti-inflammatory cytokines increased while inflammatory biomarkers decreased in a separate murine model of colorectal cancer. Resveratrol treatment significantly increased beneficial bacteria that have been negatively correlated with tumor numbers, such as Ruminococcus gnavus and Akkermansia muciniphila.

A diet rich in polyphenols can help support a healthy gut, which can have far-reaching effects. Here are a few ways you can incorporate polyphenols into the diet:.

There are certain medications that may interact with plant-based foods. Am citit totul despre polifenoli și influența lor benefică asupra intestinului. Impresionantă muncă cu rezultate pe măsură. Thank you for this in-depth dive into the effects of plant-derived polyphenols on our microbiome!

And thus our health! The complexity of interactions between our microbiota and our bodies is really mind boggling. Thankfully we only need to eat a diversity of plants in order to promote optimal health.

Especially wild harvested herbs have highly concentrated amounts of polyphenols. Drinking herbal teas is the most pleasurable way to increase your intake of a wider variety of polyphenols than just consuming green tea or eating dark chocolate with a glass of red wine!

So many delicious options for providing our bodies with polyphenols! Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. Deanna Minich is an internationally-recognized teacher, author, scientist, speaker, and artist.

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This means that the first step to improving gut health is to achieve an appropriate body weight and normalize glucose levels. While engaged in this process, it would be wise to take both supplemental probiotics and polyphenols.

It turns that the polyphenols in vegetation have a profound modulatory effect on our gut microbiota 5. In fact, evidence suggests that carotenoids from vegetation are readily absorbed, while polyphenols are absorbed less efficiently and so travel to the colon where they modulate bacteria to help maintain a state of homeostasis and symbiosis with human cells 6.

Ginger is one of the best sources of anti-inflammatory polyphenols, because it is very cheap as the raw herb or as a supplement. Turmeric is more expensive than ginger and is known to be poorly absorbed, which is why it is great for gut health. To be clear, all polyphenols have a beneficial effect on the gut, so your supplemental and dietary options are vast.

References 1. Kemperman RA et al. Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities. Moco S et al. Metabolomics view on gut microbiome modulation by polyphenol-rich foods.

J Proteome Res. Odunta SA. African fermented foods: from art to science. MIRCEN Journal. Anukam KC, Reid G. African traditional fermented foods and probiotics.

J Med Food. Rastmanesh R. High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction. Chemico-Biological Interaçtions. Seaman DR. The DeFlame Diet: DeFlame you Diet, Body, and Mind.

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Plant-based diets are associated Anf lower disease risks. As purely natural foods, they contain natural helth and nutrients Polyphemols provide several Polyphenols and gut health Appetite suppressant for men. One of these chemicals is polyphenols. Polyphenols are a group of natural chemicals that give color and taste to fruits and vegetables. They contain antioxidants that help prevent inflammation and other illnesses. They are also crucial for your health, especially your gut microbiome, and can help you live longer. Polyphenols play gur important Polyphenols and gut health Fiber for preventing diverticulosis our gut health hfalth well Pplyphenols our overall health. Polyphenols hwalth naturally occurring constituents in plant foods that give Polyphenols and gut health, such as berries, their rich, hewlth colours. Polyphenols and gut health only are polyphenol-rich foods high in antioxidants, they also provide excellent support for the healthy growth and maintenance of our gut flora our microbiota. Additionally, polyphenols can also exert anti-inflammatory, antidiabetic and anticarcinogenic effects as well as supporting cardiac health, which was well described in the review by Aravind et al, in Without a healthy and diverse gut microbiota, we would be unable to utilise polyphenols in our foods.