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Glutathione and free radicals

Glutathione and free radicals

Pattern recognition proteins: first line Glutafhione defense against coronaviruses. Article CAS Google Scholar Shigenaga, M. Gadaleta, M. Many Glutathiobe and systemic diseases especially diseases Gultathione are leading causes Glutathioje death globally like raidcals obstructive pulmonary disease, Glutathione and free radicals Glutathkone ischemic heart disease and stroke, cancer and severe raxicals respiratory syndrome coronavirus fref SARS-CoV-2 radiclas coronavirus disease 19 COVIDinvolve both, 1 oxidative stress Glutathions excessive production Glutathione and free radicals reactive oxygen species Glutathione and free radicals Autophagy and mitochondrial function lower Glutathione and free radicals GSH levels, and 2 inflammation. The GSH tripeptide γ- Athletic training adaptationsthe most abundant water-soluble Gultathione thiol in the cell 1—10 Nutrition for injury prevention is fundamental for life by a sustaining the adequate redox freee signaling needed Gluttahione maintain physiologic levels of oxidative stress fundamental to Glutathione and free radicals life processes, and b limiting excessive oxidative stress that causes cell and tissue damage. GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 Keap1 -Nuclear factor erythroid 2-related factor 2 Nrf2 -antioxidant response element ARE redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses. GSH depletion may play a central role in inflammatory diseases and COVID pathophysiology, host immune response and disease severity and mortality. Therapies enhancing GSH could become a cornerstone to reduce severity and fatal outcomes of inflammatory diseases and COVID and increasing GSH levels may prevent and subdue these diseases. The life value of GSH makes for a paramount research field in biology and medicine and may be key against systemic inflammation and SARS-CoV-2 infection and COVID disease. In this review, we emphasize on 1 GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis ischemic heart disease and stroke2 importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID disease, 3 significance of GSH to counteract persistent damaging inflammation, inflammaging and early premature inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and 4 new Gluatthione that include antioxidant defenses restoration.

Author: JoJogore

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